HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-Thiazolecarboxylic acid, 2-methyl-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 2-methyl-1,3-thiazole-5-carboxylate | HCID 12808791 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-Thiazolecarboxylic acid, 2-methyl- | HCID 98845 | 70% |
Reaction Steps
To a stirred solution of 2-methyl-thiazole-5-carboxylic acid ethyl ester (1.3 g, 8.0 mmol) in dioxane (12 mL) at room temperature was added NaOH (2N, 12 mL). After 1 h the reaction mixture was neutralized with HCl (1N, 12 mL), then filtered and the collected solid dried in vacuo to give the title compound (758 mg, 70%) as an off white solid. MS: m/e=142.0 [M−H]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178522B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-3d341b552a3b455e8acda0fed8fb1a54 |
| Source note | uspto-grants-2012_05 |