Hydrochloric Acid → 5-Thiazolecarboxylic acid, 2-methyl-

HRID 1923494Notes

Reaction equation

HRID 1923494 reaction equation
C([O:3][C:4]([C:6]1[S:10][C:9]([CH3:11])=[N:8][CH:7]=1)=[O:5])C.[OH-].[Na+].Cl>O1CCOCC1>[CH3:11][C:9]1[S:10][C:6]([C:4]([OH:5])=[O:3])=[CH:7][N:8]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12808791Ethyl 2-methyl-1,3-thiazole-5-carboxylate

Product 1

HCID 988455-Thiazolecarboxylic acid, 2-methyl-Yield 70%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a stirred solution of 2-methyl-thiazole-5-carboxylic acid ethyl ester (1.3 g, 8.0 mmol) in dioxane (12 mL) at room temperature was added NaOH (2N, 12 mL). After 1 h the reaction mixture was neutralized with HCl (1N, 12 mL), then filtered and the collected solid dried in vacuo to give the title compound (758 mg, 70%) as an off white solid. MS: m/e=142.0 [M−H]−.

Workup

  1. filtrationfiltered
  2. customthe collected solid dried in vacuo

Sources & evidence

ORD record
ord-3d341b552a3b455e8acda0fed8fb1a54
Source dataset
uspto-grants-2012_05
Patent number
US08178522B2

Reaction notes

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