3-Thiophenamine, tetrahydro-, 1,1-dioxide → HCID 59568523, compound

HRID 1923515Notes

Reaction equation

HRID 1923515 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=2)[C:3]=1[CH2:13][CH2:14][C:15]1[S:16][C:17]([C:20]([OH:22])=O)=[CH:18][N:19]=1.[O:23]=[S:24]1(=[O:30])[CH2:28][CH2:27][CH:26]([NH2:29])[CH2:25]1>>[O:23]=[S:24]1(=[O:30])[CH2:28][CH2:27][CH:26]([NH:29][C:20]([C:17]2[S:16][C:15]([CH2:14][CH2:13][C:3]3[C:4]([C:7]4[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=4)=[N:5][O:6][C:2]=3[CH3:1])=[N:19][CH:18]=2)=[O:22])[CH2:25]1

Participants

3

Reactant 2

HCID 228073-Thiophenamine, tetrahydro-, 1,1-dioxideHCID 66643592HCID 66643592, compound

Product 1

HCID 59568523HCID 59568523, compoundYield 37%

Procedure

As described for example 22b, 2-[2-(5-methyl-3-pyridin-2-yl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid (73 mg, 0.23 mmol) was converted, using 1,1-dioxidotetrahydrothien-3-ylamine instead of isopropylamine, to the title compound (37 mg, 37%) which was obtained as a brown solid MS: m/e=433.3 [M+H]+.

Sources & evidence

ORD record
ord-94a8bbe9b9ad4df1bc7b8761edcc07c0
Source dataset
uspto-grants-2012_05
Patent number
US08178522B2

Reaction notes

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