Ethanamine, 2,2,2-trifluoro- → HCID 49783338, compound

HRID 1923516Notes

Reaction equation

HRID 1923516 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=2)[C:3]=1[CH2:13][CH2:14][C:15]1[S:16][C:17]([C:20]([OH:22])=O)=[CH:18][N:19]=1.[F:23][C:24]([F:28])([F:27])[CH2:25][NH2:26]>>[F:23][C:24]([F:28])([F:27])[CH2:25][NH:26][C:20]([C:17]1[S:16][C:15]([CH2:14][CH2:13][C:3]2[C:4]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=3)=[N:5][O:6][C:2]=2[CH3:1])=[N:19][CH:18]=1)=[O:22]

Participants

3

Reactant 2

HCID 9773Ethanamine, 2,2,2-trifluoro-HCID 66643592HCID 66643592, compound

Product 1

HCID 49783338HCID 49783338, compoundYield 79%

Procedure

As described for example 22b, 2-[2-(5-methyl-3-pyridin-2-yl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid (73 mg, 0.23 mmol) was converted, using 2,2,2-trifluoroethylamine instead of isopropylamine, to the title compound (72 mg, 79%) which was obtained as an off white solid MS: m/e=397.2 [M+H]+.

Sources & evidence

ORD record
ord-e9a9e326356b4beba027ec9adb7af2dc
Source dataset
uspto-grants-2012_05
Patent number
US08178522B2

Reaction notes

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