HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxolan-3-amine → Rac-2-[2-(3-butyl-5-methyl-isoxazol-4-yl)-ethyl]-4-methyl-thiazole-5-carboxylic acid (tetrahydro-furan-3-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxolan-3-amine | HCID 3365553 | — |
| Reactant | 2-[2-(3-Butyl-5-methyl-isoxazol-4-yl)-ethyl]-4-methyl-thiazole-5-carboxylic acid | HCID 66643669 | — |
| Product | Rac-2-[2-(3-butyl-5-methyl-isoxazol-4-yl)-ethyl]-4-methyl-thiazole-5-carboxylic acid (tetrahydro-furan-3-yl)-amide | HCID 49782041 | 40% |
Reaction Steps
As described for example 48e, 2-[2-(3-butyl-5-methyl-isoxazol-4-yl)-ethyl]-4-methyl-thiazole-5-carboxylic acid (75 mg, 0.23 mmol) was converted, using rac-tetrahydrofuran-3-amine instead of isopropylamine, to the title compound (35 mg, 40%) which was obtained as a light brown oil. MS: m/e=378.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178522B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-043890f101ce4d08a50a79dea6f73ed5 |
| Source note | uspto-grants-2012_05 |