反应详情

As described for example 63b, 2-[(E)-2-(5-methyl-3-phenyl-isoxazol-4-yl)-vinyl]-thiazole-5-carboxylic acid ethyl ester (50 mg, 0.15 mmol) was converted, using isopropylamine instead of 4-aminotetrahydropyran, to the title compound (37 mg, 71%) which was obtained as a white solid. MS: m/e=354.4 [M+H]+.