HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropylamine → 2-[(E)-2-(5-Methyl-3-phenyl-isoxazol-4-yl)-vinyl]-thiazole-5-carboxylic acid isoprop-ylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | HCID 66643683 | HCID 66643683 | — |
| Product | 2-[(E)-2-(5-Methyl-3-phenyl-isoxazol-4-yl)-vinyl]-thiazole-5-carboxylic acid isoprop-ylamide | HCID 49781810 | 71% |
Reaction Steps
As described for example 63b, 2-[(E)-2-(5-methyl-3-phenyl-isoxazol-4-yl)-vinyl]-thiazole-5-carboxylic acid ethyl ester (50 mg, 0.15 mmol) was converted, using isopropylamine instead of 4-aminotetrahydropyran, to the title compound (37 mg, 71%) which was obtained as a white solid. MS: m/e=354.4 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178522B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-b51017a9cb00495f9e1c634a814b4222 |
| Source note | uspto-grants-2012_05 |