反应详情

温度

90 °C

Concentrated sulfuric acid (9.3 mL) was added to 2-{2-[3-(5-fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-yl]-2-hydroxy-ethyl}-4-methyl-thiazole-5-carboxylic acid (574 mg, 1.58 mmol) then the mixture was heated at 90° C. for 10 min. After cooling to room temperature the mixture was poured into ice (100 g) and the precipitate was filtered off and dried to give the title product. (471 mg, 86%) as a yellow solid. MS: m/e=344.1 [M−H]−.

1. temperatureAfter cooling to room temperature the mixture
2. filtrationthe precipitate was filtered off
3. customdried