Sulfuric Acid → 2-{(E)-2-[3-(5-Fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-yl]-vinyl}-4-methyl-thiazole-5-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

Concentrated sulfuric acid (9.3 mL) was added to 2-{2-[3-(5-fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-yl]-2-hydroxy-ethyl}-4-methyl-thiazole-5-carboxylic acid (574 mg, 1.58 mmol) then the mixture was heated at 90° C. for 10 min. After cooling to room temperature the mixture was poured into ice (100 g) and the precipitate was filtered off and dried to give the title product. (471 mg, 86%) as a yellow solid. MS: m/e=344.1 [M−H]−.

Provenance & Evidence