HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclobutylamine → HCID 49781371, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclobutylamine | HCID 75645 | — |
| Reactant | 2-[(E)-2-(3-Butyl-5-methyl-isoxazol-4-yl)-vinyl]-4-methyl-thiazole-5-carboxylic acid | HCID 59568539 | — |
| Product | HCID 49781371 | HCID 49781371 | 15% |
Reaction Steps
As described for example 108, 2-[(E)-2-(3-butyl-5-methyl-isoxazol-4-yl)-vinyl]-4-methyl-thiazole-5-carboxylic acid (400 mg, 1.3 mmol) was converted, using cyclobutylamine instead of 3,3-difluoroazetidine hydrochloride, to the title compound (68 mg, 15%) which was obtained as a white solid. MS: m/e=360.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178522B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-93793ced31a04aecb124810e9225abd4 |
| Source note | uspto-grants-2012_05 |