Cyclobutylamine → HCID 49781371, compound

HRID 1923628Notes

Reaction equation

HRID 1923628 reaction equation
[CH2:1]([C:5]1[C:9](/[CH:10]=[CH:11]/[C:12]2[S:13][C:14]([C:18]([OH:20])=O)=[C:15]([CH3:17])[N:16]=2)=[C:8]([CH3:21])[O:7][N:6]=1)[CH2:2][CH2:3][CH3:4].[CH:22]1([NH2:26])[CH2:25][CH2:24][CH2:23]1>>[CH:22]1([NH:26][C:18]([C:14]2[S:13][C:12](/[CH:11]=[CH:10]/[C:9]3[C:5]([CH2:1][CH2:2][CH2:3][CH3:4])=[N:6][O:7][C:8]=3[CH3:21])=[N:16][C:15]=2[CH3:17])=[O:20])[CH2:25][CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 75645CyclobutylamineHCID 595685392-[(E)-2-(3-Butyl-5-methyl-isoxazol-4-yl)-vinyl]-4-methyl-thiazole-5-carboxylic acid

Product 1

HCID 49781371HCID 49781371, compoundYield 15%

Procedure

As described for example 108, 2-[(E)-2-(3-butyl-5-methyl-isoxazol-4-yl)-vinyl]-4-methyl-thiazole-5-carboxylic acid (400 mg, 1.3 mmol) was converted, using cyclobutylamine instead of 3,3-difluoroazetidine hydrochloride, to the title compound (68 mg, 15%) which was obtained as a white solid. MS: m/e=360.2 [M+H]+.

Sources & evidence

ORD record
ord-93793ced31a04aecb124810e9225abd4
Source dataset
uspto-grants-2012_05
Patent number
US08178522B2

Reaction notes

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