反应详情

NaOH (6 M, 200 ml, 1200 mmole) was added to a solution of tert.-butyl 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetate (26.8 g, 62.7 mmole) in THF (200 ml) and methanol (200 ml). The reaction mixture was stirred at RT. After 1 hour the organic solvent was distilled off on a rotary evaporator and HCl (6 M, 210 ml) was added at 0° C. The aqueous phase was extracted with DCM (200 ml) and ethyl acetate (200 ml). The combined organic phases were dried over sodium sulfate and concentrated. Diisopropyl ether was added twice and evaporated. Yield: 21.92 g, 94%.

1. distillationAfter 1 hour the organic solvent was distilled off on a rotary evaporator and HCl (6 M, 210 ml)
2. additionwas added at 0° C
3. extractionThe aqueous phase was extracted with DCM (200 ml) and ethyl acetate (200 ml)
4. dry with materialThe combined organic phases were dried over sodium sulfate
5. concentrationconcentrated
6. additionDiisopropyl ether was added twice
7. customevaporated