HCID 49781788, compound → HCID 49781789, compound

HRID 1924020Notes

Reaction equation

HRID 1924020 reaction equation
[C:1]([OH:8])(=[O:7])[CH2:2][CH2:3][C:4]([OH:6])=[O:5].C(O)(=O)CCC(O)=O.[F:17][C:18]1[CH:23]=[C:22]([CH2:24][N:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)[C:21]([F:31])=[CH:20][C:19]=1[NH:32][C:33]1[N:38]=[C:37]([C:39]2[N:43]([CH:44]3[CH2:49][CH2:48][O:47][CH2:46][CH2:45]3)[C:42]([CH3:50])=[N:41][CH:40]=2)[C:36]([F:51])=[CH:35][N:34]=1>C(OC(=O)C)C.CO>[C:1]([OH:8])(=[O:7])[CH2:2][CH2:3][C:4]([OH:6])=[O:5].[F:17][C:18]1[CH:23]=[C:22]([CH2:24][N:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)[C:21]([F:31])=[CH:20][C:19]=1[NH:32][C:33]1[N:38]=[C:37]([C:39]2[N:43]([CH:44]3[CH2:49][CH2:48][O:47][CH2:46][CH2:45]3)[C:42]([CH3:50])=[N:41][CH:40]=2)[C:36]([F:51])=[CH:35][N:34]=1.[F:17][C:18]1[CH:23]=[C:22]([CH2:24][N:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)[C:21]([F:31])=[CH:20][C:19]=1[NH:32][C:33]1[N:38]=[C:37]([C:39]2[N:43]([CH:44]3[CH2:49][CH2:48][O:47][CH2:46][CH2:45]3)[C:42]([CH3:50])=[N:41][CH:40]=2)[C:36]([F:51])=[CH:35][N:34]=1

Participants

4

Reactant 1

HCID 49781788HCID 49781788, compound

Product 1

HCID 49781789HCID 49781789, compoundYield 44.1%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

N-(2,5-Difluoro-4-(morpholinomethyl)phenyl)-5-fluoro-4-(2-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)pyrimidin-2-amine disuccinate (1.08 g) was slurried in a mixture of ethylacetate (10 ml) and methanol (10 ml) in room temperature for 24 hrs. The solids were filtered and dried at 40° C. in vacuo to give N-(2,5-Difluoro-4-(morpholinomethyl)phenyl)-5-fluoro-4-(2-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)pyrimidin-2-amine hemisuccinate salt (0.36 g) as a crystalline solid.

Workup

  1. filtrationThe solids were filtered
  2. customdried at 40° C. in vacuo

Sources & evidence

ORD record
ord-0a23eb96ac864dc5b8322d2f8e693c4a
Source dataset
uspto-grants-2012_05
Patent number
US08178529B2

Reaction notes

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