HRID1924020
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
N-(2,5-Difluoro-4-(morpholinomethyl)phenyl)-5-fluoro-4-(2-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)pyrimidin-2-amine disuccinate (1.08 g) was slurried in a mixture of ethylacetate (10 ml) and methanol (10 ml) in room temperature for 24 hrs. The solids were filtered and dried at 40° C. in vacuo to give N-(2,5-Difluoro-4-(morpholinomethyl)phenyl)-5-fluoro-4-(2-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)pyrimidin-2-amine hemisuccinate salt (0.36 g) as a crystalline solid.
WORKUP
后处理
- filtrationThe solids were filtered
- customdried at 40° C. in vacuo