Hydrochloric Acid → N-(4-(((3S,5S)-3,5-Dimethylmorpholino)methyl)-2,5-difluorophenyl)-5-fluoro-4-(2-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)pyrimidin-2-amine hydrochloride

HRID 1924024Notes

Reaction equation

HRID 1924024 reaction equation
[CH3:1][C@@H:2]1[N:7]([CH2:8][C:9]2[C:14]([F:15])=[CH:13][C:12]([NH:16][C:17]3[N:22]=[C:21]([C:23]4[N:27]([CH:28]5[CH2:33][CH2:32][O:31][CH2:30][CH2:29]5)[C:26]([CH3:34])=[N:25][CH:24]=4)[C:20]([F:35])=[CH:19][N:18]=3)=[C:11]([F:36])[CH:10]=2)[C@@H:6]([CH3:37])[CH2:5][O:4][CH2:3]1.[ClH:38]>ClCCl>[ClH:38].[CH3:1][C@@H:2]1[N:7]([CH2:8][C:9]2[C:14]([F:15])=[CH:13][C:12]([NH:16][C:17]3[N:22]=[C:21]([C:23]4[N:27]([CH:28]5[CH2:33][CH2:32][O:31][CH2:30][CH2:29]5)[C:26]([CH3:34])=[N:25][CH:24]=4)[C:20]([F:35])=[CH:19][N:18]=3)=[C:11]([F:36])[CH:10]=2)[C@@H:6]([CH3:37])[CH2:5][O:4][CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 49782014N-(4-(((3S,5S)-3,5-Dimethylmorpholino)methyl)-2,5-difluorophenyl)-5-fluoro-4-(2-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)pyrimidin-2-amine

Product 1

HCID 49782252N-(4-(((3S,5S)-3,5-Dimethylmorpholino)methyl)-2,5-difluorophenyl)-5-fluoro-4-(2-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)pyrimidin-2-amine hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

N-(4-(((3S,5S)-3,5-dimethylmorpholino)methyl)-2,5-difluorophenyl)-5-fluoro-4-(2-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)pyrimidin-2-amine (16 mg) was dissolved in dichloromethane (4 ml) and HCl (1M in diethyl ether, 0.05 ml) was added. The solvents were evaporated to give the title compound (0.015 g) as a solid.

Workup

  1. customThe solvents were evaporated

Sources & evidence

ORD record
ord-41addefe23d442708ddf864b4c61529d
Source dataset
uspto-grants-2012_05
Patent number
US08178529B2

Reaction notes

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