Methanol → N,2-dimethylpyrimidin-4-amine

Temperature

40 °C

An autoclave was charged with 2-methyl-pyrimidine-4-carbaldehyde oxime (13 g) from I.1.2, 150 ml of methanol and 70 ml of triethylamine. The autoclave was purged with nitrogen. To this mixture was added 3 g of a 10% palladium-on-carbon catalyst. The autoclave was sealed and purged twice with hydrogen gas. The hydrogenation was run for 2 h. In doing this, the reaction mixture was warmed up to 40° C. in the meantime. The precipitate was filtered off, washed with methanol to yield the title compound as light red solid (11 g, 94%).

1. customThe autoclave was purged with nitrogen
2. additionTo this mixture was added 3 g of a 10% palladium-on-carbon catalyst
3. customThe autoclave was sealed
4. custompurged twice with hydrogen gas
5. filtrationThe precipitate was filtered off
6. washwashed with methanol

ORD record

ord-3dc1455a303b4770913440a7edbc1cad

Source dataset

uspto-grants-2012_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08178540B2