1,4-Dioxane hydrochloride → HCID 44549476, compound

HRID 1924374Notes

Reaction equation

HRID 1924374 reaction equation
C(OC([NH:8][C@H:9]([C:13]([N:15]1[CH2:23][C@H:22]([O:24][C:25]2[C:34]3[C:29](=[CH:30][CH:31]=[C:32]([CH:35]=[CH2:36])[CH:33]=3)[CH:28]=[CH:27][N:26]=2)[CH2:21][C@H:16]1[C:17]([O:19][CH3:20])=[O:18])=[O:14])[CH:10]([CH3:12])[CH3:11])=O)(C)(C)C.[ClH:37].O1CCOCC1>>[ClH:37].[NH2:8][C@H:9]([C:13]([N:15]1[CH2:23][C@H:22]([O:24][C:25]2[C:34]3[C:29](=[CH:30][CH:31]=[C:32]([CH:35]=[CH2:36])[CH:33]=3)[CH:28]=[CH:27][N:26]=2)[CH2:21][C@H:16]1[C:17]([O:19][CH3:20])=[O:18])=[O:14])[CH:10]([CH3:12])[CH3:11]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 44550117HCID 44550117, compound

Product 1

HCID 44549476HCID 44549476, compound

Procedure

A 0.27 M solution of carbamate from Step 1 in 4N HCl/dioxane was stirred at RT for 2 h. The volatiles were then removed under reduced pressure to give the title compound as an off-white solid that was used directly in the next step. MS (ES+) C22H27N3O4 requires: 397. Found: 398 (M+H+).

Workup

  1. customThe volatiles were then removed under reduced pressure

Sources & evidence

ORD record
ord-af658bcef1fa405f88d5a7ae7f2f3eae
Source dataset
uspto-grants-2012_05
Patent number
US08178520B2

Reaction notes

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