反应详情

温度

110 °C

A vigorously stirred suspension of 2-(trifluoromethyl)benzonitrile (2-A) (6.34 g, 37 mmol), sodium azide (4.81 g, 74 mmol) and triethylamine hydrochloride (10.19 g, 74 mmol) in toluene (70 mL) was heated at 110° C. for 48 h. The mixture was cooled and extracted twice with water. The combined extracts were washed with hexane and brought to pH about 1 with concentrated HCl. The precipitate which formed was filtered, washed with water and dried to give 5-[2-(trifluoromethyl)phenyl]-1H-tetrazole (2-B).

1. temperatureThe mixture was cooled
2. extractionextracted twice with water
3. washThe combined extracts were washed with hexane
4. customThe precipitate which formed
5. filtrationwas filtered
6. washwashed with water
7. customdried