o-(Trifluoromethyl)benzaldehyde → HCID 59532609, compound

HRID 1924432Notes

Reaction equation

HRID 1924432 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH:5]=O.[CH:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][C:14]=1[C:23]([NH:25][NH2:26])=[O:24]>C(O)C>[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1/[CH:5]=[N:26]/[NH:25][C:23]([C:14]1[CH:15]=[CH:16][C:17]2[C:22](=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:13]=1)=[O:24]

Participants

4

Reactant 2

HCID 123067o-(Trifluoromethyl)benzaldehydeHCID 1234852-Naphthohydrazide

Product 1

HCID 59532609HCID 59532609, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
70 °C

Procedure

2-(Trifluoromethyl)benzaldehyde (4-B) (135 μL, 1.0 mmol) was added to a partial solution of 2-naphthohydrazide (4-A) (186 mg, 1.0 mmol) in ethanol (4 mL) at 70° C. and the mixture stirred at 70° C. for 2 h. The mixture was cooled and the thick precipitate was filtered, washed with cold ethanol and dried to give N′-{(1E)-[2-(trifluoromethyl)phenyl]-methylene}-2-naphthohydrazide (4-C).

Workup

  1. temperatureThe mixture was cooled
  2. filtrationthe thick precipitate was filtered
  3. washwashed with cold ethanol
  4. customdried

Sources & evidence

ORD record
ord-7a8f44ca3e7d4de5966bbc5a4bb63691
Source dataset
uspto-grants-2012_05
Patent number
US08178546B2

Reaction notes

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