Hydrochloric Acid → 3-[2-(2-Methoxy-phenyl)-2H-pyrazol-3-yl]-1-phenyl-1H-pyridazin-4-one

HRID 1924484Notes

Reaction equation

HRID 1924484 reaction equation
C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:8]=1)=O.[CH3:21][O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[NH:29]N.Cl>>[CH3:21][O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[N:29]1[C:5]([C:7]2[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:8]=2)=[CH:4][CH:3]=[N:2]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 415063(2-Methoxyphenyl)hydrazine monohydrochlorideHCID 12742246(E)-3-(3-(Dimethylamino)acryloyl)-1-phenylpyridazin-4(1H)-one

Product 1

HCID 593699963-[2-(2-Methoxy-phenyl)-2H-pyrazol-3-yl]-1-phenyl-1H-pyridazin-4-oneYield 61%

Procedure

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-phenyl-1H-pyridazin-4-one (A-1) and 2-methoxy-phenylhydrazine×HCl according to the method described for Example 1 in 61% yield. MS: M=345.1 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-708ce26ea7e742b584f44021eace7a3f
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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