(3-(Trifluoromethyl)phenyl)hydrazine → 1-Phenyl-3-[2-(3-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one

HRID 1924486Notes

Reaction equation

HRID 1924486 reaction equation
C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:8]=1)=O.[F:21][C:22]([F:32])([F:31])[C:23]1[CH:24]=[C:25]([NH:29]N)[CH:26]=[CH:27][CH:28]=1>>[C:14]1([N:9]2[CH:10]=[CH:11][C:12](=[O:13])[C:7]([C:5]3[N:29]([C:25]4[CH:26]=[CH:27][CH:28]=[C:23]([C:22]([F:21])([F:31])[F:32])[CH:24]=4)[N:2]=[CH:3][CH:4]=3)=[N:8]2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 98650(3-(Trifluoromethyl)phenyl)hydrazineHCID 12742246(E)-3-(3-(Dimethylamino)acryloyl)-1-phenylpyridazin-4(1H)-one

Product 1

HCID 462191931-Phenyl-3-[2-(3-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-1H-pyridazin-4-oneYield 58%

Procedure

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-phenyl-1H-pyridazin-4-one (A-1) and 3-(trifluoromethyl)-phenylhydrazine according to the method described for Example 1 in 58% yield. MS: M=383.0 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-cc2d1d4274fe4e11a9f7772eb13e2519
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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