HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Trifluoromethyl)phenylhydrazine → 1-(3-Trifluoromethyl-phenyl)-3-[2-(2-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Trifluoromethyl)phenylhydrazine | HCID 520800 | — |
| Reactant | 3-((E)-3-Dimethylamino-acryloyl)-1-(3-trifluoromethyl-phenyl)-1H-pyridazin-4-one | HCID 59370027 | — |
| Product | 1-(3-Trifluoromethyl-phenyl)-3-[2-(2-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one | HCID 46219456 | 46% |
Reaction Steps
The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-(3-trifluoromethyl-phenyl)-1H-pyridazin-4-one (A-3) and o-trifluoromethyl-phenylhydrazine according to the method described for Example 1 in 46% yield. MS: M=451.1 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178538B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-f0926d67d3e94bb8830e098f8a946c0f |
| Source note | uspto-grants-2012_05 |