2-(Trifluoromethyl)phenylhydrazine → 1-(3-Trifluoromethyl-phenyl)-3-[2-(2-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one

HRID 1924488Notes

Reaction equation

HRID 1924488 reaction equation
C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=2)[N:8]=1)=O.[F:25][C:26]([F:36])([F:35])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[NH:33]N>>[F:21][C:20]([F:23])([F:22])[C:16]1[CH:15]=[C:14]([N:9]2[CH:10]=[CH:11][C:12](=[O:13])[C:7]([C:5]3[N:33]([C:28]4[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=4[C:26]([F:25])([F:35])[F:36])[N:2]=[CH:3][CH:4]=3)=[N:8]2)[CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 5208002-(Trifluoromethyl)phenylhydrazineHCID 593700273-((E)-3-Dimethylamino-acryloyl)-1-(3-trifluoromethyl-phenyl)-1H-pyridazin-4-one

Product 1

HCID 462194561-(3-Trifluoromethyl-phenyl)-3-[2-(2-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-1H-pyridazin-4-oneYield 46%

Procedure

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-(3-trifluoromethyl-phenyl)-1H-pyridazin-4-one (A-3) and o-trifluoromethyl-phenylhydrazine according to the method described for Example 1 in 46% yield. MS: M=451.1 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-f0926d67d3e94bb8830e098f8a946c0f
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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