Hydrochloric Acid → 3-[1-(4-methoxyphenyl)-1H-pyrazol-5-yl]-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one

HRID 1924518Notes

Reaction equation

HRID 1924518 reaction equation
C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=2)[N:8]=1)=O.[CH3:25][O:26][C:27]1[CH:32]=[CH:31][C:30]([NH:33]N)=[CH:29][CH:28]=1.Cl>>[CH3:25][O:26][C:27]1[CH:32]=[CH:31][C:30]([N:33]2[C:5]([C:7]3[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]4[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=4)[N:8]=3)=[CH:4][CH:3]=[N:2]2)=[CH:29][CH:28]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 77023(4-Methoxyphenyl)hydrazineHCID 593700273-((E)-3-Dimethylamino-acryloyl)-1-(3-trifluoromethyl-phenyl)-1H-pyridazin-4-one

Product 1

HCID 462198173-[1-(4-methoxyphenyl)-1H-pyrazol-5-yl]-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-oneYield 10%

Procedure

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-(3-trifluoromethyl-phenyl)-1H-pyridazin-4-one (A-3) and 4-methoxy-phenylhydrazine×HCl according to the method described for Example 1 in 10% yield. MS: M=413.5 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-5c2794a21f124efdaab140b0ac78a998
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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