4-Hydrazinobenzoic acid → 4-{5-[4-Oxo-1-(3-trifluoromethoxy-phenyl)-1,4-dihydro-pyridazin-3-yl]-pyrazol-1-yl}-benzoic acid

HRID 1924522Notes

Reaction equation

HRID 1924522 reaction equation
C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([O:20][C:21]([F:24])([F:23])[F:22])[CH:15]=2)[N:8]=1)=O.[NH:26]([C:28]1[CH:36]=[CH:35][C:31]([C:32]([OH:34])=[O:33])=[CH:30][CH:29]=1)N>>[O:13]=[C:12]1[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([O:20][C:21]([F:24])([F:23])[F:22])[CH:15]=2)[N:8]=[C:7]1[C:5]1[N:26]([C:28]2[CH:36]=[CH:35][C:31]([C:32]([OH:34])=[O:33])=[CH:30][CH:29]=2)[N:2]=[CH:3][CH:4]=1

Participants

3

Reactant 2

HCID 120894-Hydrazinobenzoic acidHCID 593701233-((E)-3-Dimethylamino-acryloyl)-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-one

Product 1

HCID 462199344-{5-[4-Oxo-1-(3-trifluoromethoxy-phenyl)-1,4-dihydro-pyridazin-3-yl]-pyrazol-1-yl}-benzoic acid

Procedure

Reaction of 3-((E)-3-Dimethylamino-acryloyl)-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-one (A-6) and 4-hydrazino-benzoic acid according to example 43 gave the desired product. MS: M=442.9 (M)+

Sources & evidence

ORD record
ord-87e5cc3f2bc443eab551539708255a19
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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