反应详情

3-((E)-3-Dimethylamino-acryloyl)-1-(3-methansulfonyl-phenyl)-1H-pyridazin-4-one (A-7) (0.05 g; 0.144 mmol) and 4-hydrazino-2-methylpyridine (0.03 g; 0.187 mmol) are dissolved in a sealed tube in dimethylformamide (0.6 ml) and irradiated at 180° C. for 10 min. The solvent of the reaction mixture is removed and the crude product is purified by preparative HPLC yielding 0.02 g (34.1%) of the final product. MS: M=408.4 (M+H)+

1. customirradiated at 180° C. for 10 min
2. customThe solvent of the reaction mixture is removed
3. customthe crude product is purified by preparative HPLC