Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Stannous Chloride → 1-(4-Difluoromethoxy-phenyl)-3-[2-(3-fluoro-phenyl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Stannous Chloride | HCID 24479 | — |
| 반응물 | (3-Fluorophenyl)hydrazine | HCID 581026 | — |
| 반응물 | Sodium Nitrite | HCID 23668193 | — |
| 반응물 | 1-(4-Difluoromethoxy-phenyl)-3-((E)-3-dimethylamino-acryloyl)-1H-pyridazin-4-one | HCID 59369978 | — |
| 생성물 | 1-(4-Difluoromethoxy-phenyl)-3-[2-(3-fluoro-phenyl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one | HCID 59370016 | 62% |
반응 단계
The product was obtained starting from 1-(4-Difluoromethoxy-phenyl)-3-((E)-3-dimethylamino-acryloyl)-1H-pyridazin-4-one (A-9) and (3-fluoro-phenyl)-hydrazine (prepared from the corresponding amino derivative using sodium nitrite and tin(II) chloride as described in J. Med. Chem. 2003, 46, 4676-4686) according to the method described for Example 91 in 62% yield. MS: M=399.1 (M+H)+
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08178538B2 |
| 출처 데이터셋 | uspto-grants-2012_05 |
| ORD ID | ord-884eb0c93c194684ad6dba2938f7550a |
| 출처 메모 | uspto-grants-2012_05 |