[3-(Trifluoromethoxy)phenyl]hydrazine → 1-(3-Methanesulfonyl-phenyl)-3-[2-(3-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one

HRID 1924595Notes

Reaction equation

HRID 1924595 reaction equation
C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([S:20]([CH3:23])(=[O:22])=[O:21])[CH:15]=2)[N:8]=1)=O.[F:25][C:26]([F:37])([F:36])[O:27][C:28]1[CH:29]=[C:30]([NH:34]N)[CH:31]=[CH:32][CH:33]=1>>[CH3:23][S:20]([C:16]1[CH:15]=[C:14]([N:9]2[CH:10]=[CH:11][C:12](=[O:13])[C:7]([C:5]3[N:34]([C:30]4[CH:31]=[CH:32][CH:33]=[C:28]([O:27][C:26]([F:25])([F:36])[F:37])[CH:29]=4)[N:2]=[CH:3][CH:4]=3)=[N:8]2)[CH:19]=[CH:18][CH:17]=1)(=[O:22])=[O:21]

Participants

3

Reactant 2

HCID 5194226[3-(Trifluoromethoxy)phenyl]hydrazineHCID 593701713-((E)-3-Dimethylamino-acryloyl)-1-(3-methansulfonyl-phenyl)-1H-pyridazin-4-one

Product 1

HCID 593700931-(3-Methanesulfonyl-phenyl)-3-[2-(3-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one

Procedure

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-(3-methansulfonyl-phenyl)-1H-pyridazin-4-one (A-7) and 3-trifluoromethoxy-phenylhydrazine according to the method described for example 43. MS: M=477.2 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-8a361635692b4d119990571711bec583
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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