3-Hydrazinylbenzonitrile → 3-{5-[1-(2,2-Difluoro-benzo[1,3]dioxol-4-yl)-4-oxo-1,4-dihydro-pyridazin-3-yl]-pyrazol-1-yl}-benzonitrile

HRID 1924601Notes

Reaction equation

HRID 1924601 reaction equation
[F:1][C:2]1([F:25])[O:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([N:11]3[CH:16]=[CH:15][C:14](=[O:17])[C:13]([C:18](=O)/[CH:19]=[CH:20]/[N:21](C)C)=[N:12]3)[C:4]=2[O:3]1.[NH:26]([C:28]1[CH:29]=[C:30]([CH:33]=[CH:34][CH:35]=1)[C:31]#[N:32])N>C(O)C>[F:25][C:2]1([F:1])[O:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([N:11]3[CH:16]=[CH:15][C:14](=[O:17])[C:13]([C:18]4[N:26]([C:28]5[CH:29]=[C:30]([CH:33]=[CH:34][CH:35]=5)[C:31]#[N:32])[N:21]=[CH:20][CH:19]=4)=[N:12]3)[C:4]=2[O:3]1

Participants

4

Reactant 2

HCID 14881453-HydrazinylbenzonitrileHCID 593701341-(2,2-Difluoro-benzo[1,3]dioxol-4-yl)-3-((E)-3-dimethylamino-acryloyl)-1H-pyridazin-4-one

Product 1

HCID 593700473-{5-[1-(2,2-Difluoro-benzo[1,3]dioxol-4-yl)-4-oxo-1,4-dihydro-pyridazin-3-yl]-pyrazol-1-yl}-benzonitrile

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The product was obtained starting from 1-(2,2-Difluoro-benzo[1,3]dioxol-4-yl)-3-((E)-3-dimethylamino-acryloyl)-1H-pyridazin-4-one (A-15) and 3-hydrazino-benzonitrile in ethanol as solvent according to the method described for example 91. MS: M=420.2 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-1f75eacfa4a04802b7ed182bd757d3da
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

Loading…