2-Fluorophenylhydrazine hydrochloride → 1-(4-Difluoromethoxy-phenyl)-3-[2-(2-fluoro-phenyl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one

HRID 1924637Notes

Reaction equation

HRID 1924637 reaction equation
[F:1][CH:2]([F:24])[O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:15]=[CH:14][C:13](=[O:16])[C:12]([C:17](=O)/[CH:18]=[CH:19]/[N:20](C)C)=[N:11]2)=[CH:6][CH:5]=1.[F:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[NH:32]N>>[F:1][CH:2]([F:24])[O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:15]=[CH:14][C:13](=[O:16])[C:12]([C:17]3[N:32]([C:27]4[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=4[F:25])[N:20]=[CH:19][CH:18]=3)=[N:11]2)=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 4238442-Fluorophenylhydrazine hydrochlorideHCID 593699781-(4-Difluoromethoxy-phenyl)-3-((E)-3-dimethylamino-acryloyl)-1H-pyridazin-4-one

Product 1

HCID 593700901-(4-Difluoromethoxy-phenyl)-3-[2-(2-fluoro-phenyl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one

Procedure

The product was obtained starting from 1-(4-Difluoromethoxy-phenyl)-3-((E)-3-dimethylamino-acryloyl)-1H-pyridazin-4-one (A-9) and 2-fluoro-phenylhydrazine according to the method described for example 91. MS: M=399.1 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-cbfb077a4160418f8aa600cdc20d1616
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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