(E)-3-(3-(Dimethylamino)acryloyl)-1-phenylpyridazin-4(1H)-one → 3-[2-(6-Fluoro-quinolin-4-yl)-2H-pyrazol-3-yl]-1-phenyl-1H-pyridazin-4-one

HRID 1924657Notes

Reaction equation

HRID 1924657 reaction equation
C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:8]=1)=O.[F:21][C:22]1[CH:23]=[C:24]2[C:29](=[CH:30][CH:31]=1)[N:28]=[CH:27][CH:26]=[C:25]2[NH:32]N>>[F:21][C:22]1[CH:23]=[C:24]2[C:29](=[CH:30][CH:31]=1)[N:28]=[CH:27][CH:26]=[C:25]2[N:32]1[C:5]([C:7]2[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:8]=2)=[CH:4][CH:3]=[N:2]1

Participants

3

Reactant 2

HCID 12742246(E)-3-(3-(Dimethylamino)acryloyl)-1-phenylpyridazin-4(1H)-oneHCID 170396156-Fluoro-4-hydrazinoquinoline

Product 1

HCID 593699793-[2-(6-Fluoro-quinolin-4-yl)-2H-pyrazol-3-yl]-1-phenyl-1H-pyridazin-4-one

Procedure

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-phenyl-1H-pyridazin-4-one (A-1) and (6-fluoro-quinolin-4-yl)-hydrazine according to the method described for example 1. MS: M=384.1 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-f7e5d2c8104347d091d2786181ab8cfb
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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