6-Fluoro-4-hydrazinyl-2-methyl-quinoline → 3-[2-(6-Fluoro-2-methyl-quinolin-4-yl)-2H-pyrazol-3-yl]-1-(3-methoxy-phenyl)-1H-pyridazin-4-one

HRID 1924668Notes

Reaction equation

HRID 1924668 reaction equation
C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH3:21])[CH:15]=2)[N:8]=1)=O.[F:23][C:24]1[CH:25]=[C:26]2[C:31](=[CH:32][CH:33]=1)[N:30]=[C:29]([CH3:34])[CH:28]=[C:27]2[NH:35]N>>[F:23][C:24]1[CH:25]=[C:26]2[C:31](=[CH:32][CH:33]=1)[N:30]=[C:29]([CH3:34])[CH:28]=[C:27]2[N:35]1[C:5]([C:7]2[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH3:21])[CH:15]=3)[N:8]=2)=[CH:4][CH:3]=[N:2]1

Participants

3

Reactant 2

HCID 4932356-Fluoro-4-hydrazinyl-2-methyl-quinolineHCID 593699893-((E)-3-Dimethylamino-acryloyl)-1-(3-methoxy-phenyl)-1H-pyridazin-4-one

Product 1

HCID 593701513-[2-(6-Fluoro-2-methyl-quinolin-4-yl)-2H-pyrazol-3-yl]-1-(3-methoxy-phenyl)-1H-pyridazin-4-one

Procedure

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-(3-methoxy-phenyl)-1H-pyridazin-4-one (A-5) and (6-fluoro-2-methyl-quinolin-4-yl)-hydrazine according to the method described for example 91. MS: M=428.2 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-c2c1310714e249a08335058cd44e0a02
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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