(3-Methyl-isothiazol-5-yl)-hydrazine → 3-[2-(3-Methyl-isothiazol-5-yl)-2H-pyrazol-3-yl]-1-(4-trifluoromethoxy-phenyl)-1H-pyridazin-4-one

HRID 1924688Notes

Reaction equation

HRID 1924688 reaction equation
CN(C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=2)[N:8]=1)=O.[CH3:26][C:27]1[CH:31]=[C:30]([NH:32][NH2:33])[S:29][N:28]=1>>[CH3:26][C:27]1[CH:31]=[C:30]([N:32]2[C:5]([C:7]3[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]4[CH:19]=[CH:18][C:17]([O:20][C:21]([F:23])([F:22])[F:24])=[CH:16][CH:15]=4)[N:8]=3)=[CH:4][CH:3]=[N:33]2)[S:29][N:28]=1

Participants

3

Reactant 2

HCID 55282001(3-Methyl-isothiazol-5-yl)-hydrazineHCID 593700343-((E)-3-Dimethylamino-acryloyl)-1-(4-trifluoromethoxy-phenyl)-1H-pyridazin-4-one

Product 1

HCID 593700663-[2-(3-Methyl-isothiazol-5-yl)-2H-pyrazol-3-yl]-1-(4-trifluoromethoxy-phenyl)-1H-pyridazin-4-one

Procedure

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-(4-trifluoromethoxy-phenyl)-1H-pyridazin-4-one (A-8) and (3-methyl-isothiazol-5-yl)-hydrazine according to the method described for example 43. MS: M=420.0 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-00c0357d2d1e436dbb5466a5ac4a771c
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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