8-Hydrazinylisoquinoline → 3-[3-(2-Isoquinolin-8-yl-2H-pyrazol-3-yl)-4-oxo-4H-pyridazin-1-yl]-N,N-dimethyl-benzenesulfonamide

HRID 1924722Notes

Reaction equation

HRID 1924722 reaction equation
CN(C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:15]=[C:16]([S:20]([N:23]([CH3:25])[CH3:24])(=[O:22])=[O:21])[CH:17]=[CH:18][CH:19]=2)[N:8]=1)=O.[CH:27]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][C:35]=2[NH:37][NH2:38])[CH:30]=[CH:29][N:28]=1>>[CH:27]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][C:35]=2[N:37]2[C:5]([C:7]3[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]4[CH:15]=[C:16]([S:20]([N:23]([CH3:25])[CH3:24])(=[O:22])=[O:21])[CH:17]=[CH:18][CH:19]=4)[N:8]=3)=[CH:4][CH:3]=[N:38]2)[CH:30]=[CH:29][N:28]=1

Participants

3

Reactant 2

HCID 124128578-HydrazinylisoquinolineHCID 593701633-[3-((E)-3-Dimethylamino-acryloyl)-4-oxo-4H-pyridazin-1-yl]-N,N-dimethyl-benzenesulfonamide

Product 1

HCID 593700813-[3-(2-Isoquinolin-8-yl-2H-pyrazol-3-yl)-4-oxo-4H-pyridazin-1-yl]-N,N-dimethyl-benzenesulfonamide

Procedure

The product was obtained starting from 3-[3-((E)-3-Dimethylamino-acryloyl)-4-oxo-4H-pyridazin-1-yl]-N,N-dimethyl-benzenesulfonamide (A-12) and isoquinolin-8-yl-hydrazine according to the method described for example 91. MS: M=473.3 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-2b411900d4654ee784c43243d4ddc1ca
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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