7-Chloro-4-hydrazinylquinoline → 3-[2-(7-Chloro-quinolin-4-yl)-2H-pyrazol-3-yl]-1-[3-(piperidine-1-sulfonyl)-phenyl]-1H-pyridazin-4-one

HRID 1924736Notes

Reaction equation

HRID 1924736 reaction equation
CN(C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([S:20]([N:23]3[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]3)(=[O:22])=[O:21])[CH:15]=2)[N:8]=1)=O.[Cl:30][C:31]1[CH:40]=[C:39]2[C:34]([C:35]([NH:41][NH2:42])=[CH:36][CH:37]=[N:38]2)=[CH:33][CH:32]=1>>[Cl:30][C:31]1[CH:40]=[C:39]2[C:34]([C:35]([N:41]3[C:5]([C:7]4[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]5[CH:19]=[CH:18][CH:17]=[C:16]([S:20]([N:23]6[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]6)(=[O:21])=[O:22])[CH:15]=5)[N:8]=4)=[CH:4][CH:3]=[N:42]3)=[CH:36][CH:37]=[N:38]2)=[CH:33][CH:32]=1

Participants

3

Reactant 2

HCID 321097-Chloro-4-hydrazinylquinolineHCID 593701133-((E)-3-Dimethylamino-acryloyl)-1-[3-(piperidine-1-sulfonyl)-phenyl]-1H-pyridazin-4-one

Product 1

HCID 593701063-[2-(7-Chloro-quinolin-4-yl)-2H-pyrazol-3-yl]-1-[3-(piperidine-1-sulfonyl)-phenyl]-1H-pyridazin-4-one

Procedure

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-[3-(piperidine-1-sulfonyl)-phenyl]-1H-pyridazin-4-one (A-26) and (7-chloro-quinolin-4-yl)-hydrazine according to the method described for example 91. MS: M=547.2 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-d759b30d1e6e4b21a74135fd33ab01ad
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

Loading…