2-Fluoropyridine-4-boronic acid → N-(5-(2-fluoropyridin-4-yl)thiazolo[5,4-b]pyridin-2-yl)-4-(1-hydroxy-2-methylpropan-2-yl)benzamide

Participants

Reaction Steps

The titled compound (yield=38%, light yellow solid) was prepared using a procedure analogous to that described in connection with 10 (Example 10) except that 2F (Example 2) and 2-fluoropyridin-4-ylboronic acid were used as starting materials. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.27 (s, 6H) 3.49 (d, J=3.03 Hz, 2H) 4.78 (br. s., 1H) 7.59 (d, J=8.59 Hz, 2H) 7.91 (s, 1H) 8.06-8.16 (m, 3H) 8.27-8.36 (m, 2H) 8.38 (d, J=5.31 Hz, 1H) 13.11 (s, 1H); ESI-MS: m/z 423.0 (M+H)+.

Provenance & Evidence