反应详情

A suspension of 2-ethyl-6-methyl-isonicotinic acid (2.73 g, 16.5 mmol) in THF (30 mL) is treated with borane in THF (1M, 33.1 mL) at rt for 15 h. The mixture is quenched with sat. aq. Na2CO3 (100 mL) and extracted with CHCl3 (5×50 mL). The organic extracts are dried (Na2SO4), filtered and evaporated (50 mbar, 45° C.) to give crude (2-ethyl-6-methyl-pyridin-4-yl)-methanol (2.18 g); LC-MS: tR=0.80 min, [M+1]+=205.32.

1. customThe mixture is quenched with sat. aq. Na2CO3 (100 mL)
2. extractionextracted with CHCl3 (5×50 mL)
3. dry with materialThe organic extracts are dried (Na2SO4)
4. filtrationfiltered
5. customevaporated (50 mbar, 45° C.)