1,4-Dioxane → HCID 135995201, compound

Participants

Reaction Conditions

Reaction Steps

2,4-bis(methyloxy)-5-(5-methyl-1,3,4-thiadiazol-2-yl)pyrimidine (Prep. 12, 311 mg, 1.305 mmol) was suspended in hydrochloric acid 4M in dioxane (4 ml, 16.00 mmol) and the mixture stirred at 90° C. for 4 h. Solvent was removed under reduced pressure, to give title compound (334 mg, 1.303 mmol). Crude was used in the following step without any further purification.

Provenance & Evidence