1,4-Dioxane → HCID 135995201, compound

HRID 1925017Notes

Reaction equation

HRID 1925017 reaction equation
C[O:2][C:3]1[N:8]=[C:7]([O:9]C)[C:6]([C:11]2[S:12][C:13]([CH3:16])=[N:14][N:15]=2)=[CH:5][N:4]=1.O1CCOCC1>Cl>[CH3:16][C:13]1[S:12][C:11]([C:6]2[C:7](=[O:9])[NH:8][C:3](=[O:2])[NH:4][CH:5]=2)=[N:15][N:14]=1

Participants

4

Reactant 2

HCID 312751,4-DioxaneHCID 59448345HCID 59448345, compound

Product 1

HCID 135995201HCID 135995201, compoundYield 99.8%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
90 °C

Procedure

2,4-bis(methyloxy)-5-(5-methyl-1,3,4-thiadiazol-2-yl)pyrimidine (Prep. 12, 311 mg, 1.305 mmol) was suspended in hydrochloric acid 4M in dioxane (4 ml, 16.00 mmol) and the mixture stirred at 90° C. for 4 h. Solvent was removed under reduced pressure, to give title compound (334 mg, 1.303 mmol). Crude was used in the following step without any further purification.

Workup

  1. customSolvent was removed under reduced pressure

Sources & evidence

ORD record
ord-f9b7b81175914bcf9b5cde59278f5c2d
Source dataset
uspto-grants-2012_05
Patent number
US08178549B2

Reaction notes

Loading…