HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-(2-methyl-1,3-thiazol-4-yl)-2,4(1H,3H)-pyrimidinedione hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2,4-Bis(methyloxy)-5-(2-methyl-1,3-thiazol-4-yl)pyrimidine | HCID 59448356 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-(2-methyl-1,3-thiazol-4-yl)-2,4(1H,3H)-pyrimidinedione hydrochloride | HCID 67519693 | — |
Reaction Steps
2,4-bis(methyloxy)-5-(2-methyl-1,3-thiazol-4-yl)pyrimidine (Prep19, 290 mg, 1.222 mmol) was suspended in HCl 4M in 1,4-dioxane (10 ml). The reaction mixture was heated at 90° for 1 h and left at room temperature overnight. The solvent was then removed in vacuo to give the title compound as a solid (287 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178549B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-88c614853412493e9dbabd86ffdb6fed |
| Source note | uspto-grants-2012_05 |