Hydrochloric Acid → 5-(2-methyl-1,3-thiazol-4-yl)-2,4(1H,3H)-pyrimidinedione hydrochloride

HRID 1925023Notes

Reaction equation

HRID 1925023 reaction equation
C[O:2][C:3]1[N:8]=[C:7]([O:9]C)[C:6]([C:11]2[N:12]=[C:13]([CH3:16])[S:14][CH:15]=2)=[CH:5][N:4]=1.[ClH:17]>O1CCOCC1>[ClH:17].[CH3:16][C:13]1[S:14][CH:15]=[C:11]([C:6]2[C:7](=[O:9])[NH:8][C:3](=[O:2])[NH:4][CH:5]=2)[N:12]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 594483562,4-Bis(methyloxy)-5-(2-methyl-1,3-thiazol-4-yl)pyrimidine

Product 1

HCID 675196935-(2-methyl-1,3-thiazol-4-yl)-2,4(1H,3H)-pyrimidinedione hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2,4-bis(methyloxy)-5-(2-methyl-1,3-thiazol-4-yl)pyrimidine (Prep19, 290 mg, 1.222 mmol) was suspended in HCl 4M in 1,4-dioxane (10 ml). The reaction mixture was heated at 90° for 1 h and left at room temperature overnight. The solvent was then removed in vacuo to give the title compound as a solid (287 mg).

Workup

  1. temperatureThe reaction mixture was heated at 90° for 1 h
  2. customThe solvent was then removed in vacuo

Sources & evidence

ORD record
ord-88c614853412493e9dbabd86ffdb6fed
Source dataset
uspto-grants-2012_05
Patent number
US08178549B2

Reaction notes

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