HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1925039Generated: October 30, 2026
2,4-Bis(methyloxy)-5-(4-methyl-1,3-thiazol-2-yl)pyrimidine → 5-(4-methyl-1,3-thiazol-2-yl)-2,4(1H,3H)-pyrimidinedione
https://huagongshe.com/reaction/1925039
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2,4-Bis(methyloxy)-5-(4-methyl-1,3-thiazol-2-yl)pyrimidine | HCID 59448370 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-(4-methyl-1,3-thiazol-2-yl)-2,4(1H,3H)-pyrimidinedione | HCID 135990572 | 88.3% |
Reaction Steps
2,4-bis(methyloxy)-5-(4-methyl-1,3-thiazol-2-yl)pyrimidine (Prep40, 280 mg, 0.861 mmol) was dissolved in 18 mL of hydrochloric acid 4M in dioxane and the resulting mixture was stirred in a round bottomed flask at 90° C. for 2 hours. Then it was cooled to rt and dried under vacuum to afford the title compound as a yellow solid (300 mg, 0.760 mmol)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08178549B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-94e95d24e6f843b79c08b737dba71578 |
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| Source note | uspto-grants-2012_05 |
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