反应详情

温度

90 °C

2,4-bis(methyloxy)-5-(4-methyl-1,3-thiazol-2-yl)pyrimidine (Prep40, 280 mg, 0.861 mmol) was dissolved in 18 mL of hydrochloric acid 4M in dioxane and the resulting mixture was stirred in a round bottomed flask at 90° C. for 2 hours. Then it was cooled to rt and dried under vacuum to afford the title compound as a yellow solid (300 mg, 0.760 mmol)

1. temperatureThen it was cooled to rt
2. customdried under vacuum