反应详情

5-(3-methyl-4-isothiazolyl)-2,4-bis(methyloxy)pyrimidine (Prep 46, two batches combined, 30 mg, 0.148 mmol) was suspended in a 4M solution of HYDROCHLORIC ACID (1580 μl, 6.32 mmol) in dioxane the mixture was stirred at 90° for 2.5 hours. The mixture was allowed to cool to rt and dried (rotary) to afford a yellowish solid (0.126 mmol, yield considered quantitative assuming complete conversion to target compound).

1. customdried (rotary)
2. customto afford
3. customa yellowish solid (0.126 mmol, yield considered quantitative assuming complete conversion to target compound)