Hydrochloric Acid → HCID 67519764, compound

Participants

Reaction Steps

5-(1-methyl-1H-imidazol-5-yl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione (E9, 9.4 mg, 0.020 mmol) was suspended in Diethyl ether (1 ml) and Hydrochloric acid (0.025 ml, 0.025 mmol) 1M in Et2O was added. A gum was formed and it was dissolved in MeOH and DCM (0.3 mL each) and dried. The white solid formed was triturated with Et2O (3×0.3 mL) to afford the title compound as a white solid (8.2 mg).

Provenance & Evidence