Hydrochloric Acid → HCID 67519764, compound

HRID 1925048Notes

Reaction equation

HRID 1925048 reaction equation
[CH3:1][N:2]1[C:6]([C:7]2[C:8](=[O:33])[NH:9][C:10](=[O:32])[N:11]([CH2:13][CH2:14][CH2:15][N:16]3[CH2:21][C@H:20]4[C@:18]([C:22]5[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=5)([CH2:19]4)[CH2:17]3)[CH:12]=2)=[CH:5][N:4]=[CH:3]1.[ClH:34]>C(OCC)C.CO>[ClH:34].[CH3:1][N:2]1[C:6]([C:7]2[C:8](=[O:33])[NH:9][C:10](=[O:32])[N:11]([CH2:13][CH2:14][CH2:15][N:16]3[CH2:21][C@H:20]4[C@:18]([C:22]5[CH:27]=[CH:26][C:25]([C:28]([F:29])([F:30])[F:31])=[CH:24][CH:23]=5)([CH2:19]4)[CH2:17]3)[CH:12]=2)=[CH:5][N:4]=[CH:3]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 25252824HCID 25252824, compound

Product 1

HCID 67519764HCID 67519764, compoundYield 82.7%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent2×

Procedure

5-(1-methyl-1H-imidazol-5-yl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione (E9, 9.4 mg, 0.020 mmol) was suspended in Diethyl ether (1 ml) and Hydrochloric acid (0.025 ml, 0.025 mmol) 1M in Et2O was added. A gum was formed and it was dissolved in MeOH and DCM (0.3 mL each) and dried. The white solid formed was triturated with Et2O (3×0.3 mL) to afford the title compound as a white solid (8.2 mg).

Workup

  1. customA gum was formed
  2. dry with materialDCM (0.3 mL each) and dried
  3. customThe white solid formed
  4. customwas triturated with Et2O (3×0.3 mL)

Sources & evidence

ORD record
ord-7816da9d4a764fecb9d5270bbbaed746
Source dataset
uspto-grants-2012_05
Patent number
US08178549B2

Reaction notes

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