Hydrochloric Acid → HCID 67519767, compound

Participants

Reaction Steps

1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2,4(1H,3H)-pyrimidinedione (E12, 32.7 mg, 0.065 mmol) was dissolved and sonicated in Diethyl ether (3 ml) to give a white suspension. A 1.25M solution of HCl in MeOH (0.130 ml, 0.163 mmol) was added at room temperature. The obtained mixture was sonicated for 3 min and the solvent evaporated in vacuo. Obtained 27.2 mg (72.4% yield) of the title compound as a white solid.

Provenance & Evidence