Hydrochloric Acid → HCID 67519767, compound

HRID 1925050Notes

Reaction equation

HRID 1925050 reaction equation
[F:1][C:2]([F:35])([F:34])[C:3]1[CH:8]=[CH:7][C:6]([C@:9]23[CH2:14][C@H:13]2[CH2:12][N:11]([CH2:15][CH2:16][CH2:17][N:18]2[CH:23]=[C:22]([C:24]4[C:25]([CH3:31])=[N:26][N:27]([CH3:30])[C:28]=4[CH3:29])[C:21](=[O:32])[NH:20][C:19]2=[O:33])[CH2:10]3)=[CH:5][CH:4]=1.[ClH:36].CO>C(OCC)C>[ClH:36].[ClH:36].[F:35][C:2]([F:1])([F:34])[C:3]1[CH:4]=[CH:5][C:6]([C@:9]23[CH2:14][C@H:13]2[CH2:12][N:11]([CH2:15][CH2:16][CH2:17][N:18]2[CH:23]=[C:22]([C:24]4[C:25]([CH3:31])=[N:26][N:27]([CH3:30])[C:28]=4[CH3:29])[C:21](=[O:32])[NH:20][C:19]2=[O:33])[CH2:10]3)=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 25252826HCID 25252826, compound

Product 1

HCID 67519767HCID 67519767, compoundYield 72.4%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2,4(1H,3H)-pyrimidinedione (E12, 32.7 mg, 0.065 mmol) was dissolved and sonicated in Diethyl ether (3 ml) to give a white suspension. A 1.25M solution of HCl in MeOH (0.130 ml, 0.163 mmol) was added at room temperature. The obtained mixture was sonicated for 3 min and the solvent evaporated in vacuo. Obtained 27.2 mg (72.4% yield) of the title compound as a white solid.

Workup

  1. customto give a white suspension
  2. customThe obtained mixture was sonicated for 3 min
  3. customthe solvent evaporated in vacuo

Sources & evidence

ORD record
ord-04dbdf122c254ad0a0d12ed66965c537
Source dataset
uspto-grants-2012_05
Patent number
US08178549B2

Reaction notes

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