Hydrochloric Acid → 5-(3-methyl-1H-pyrazol-1-yl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione dihydrochloride

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Reaction Steps

5-(3-methyl-1H-pyrazol-1-yl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione (E28, 51.8 mg, 0.113 mmol) was dissolved and sonicated in Diethyl ether (1 ml) to give a colorless solution. 1.25 M solution of HCl in MeOH (0.225 ml, 0.282 mmol) was added at room temperature. After 3 min and the solvent in vacuo. Obtained 50.8 mg of the title compound as a white powder.

Provenance & Evidence