Hydrochloric Acid → 5-(3-methyl-1H-pyrazol-1-yl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione dihydrochloride

HRID 1925061Notes

Reaction equation

HRID 1925061 reaction equation
[CH3:1][C:2]1[CH:6]=[CH:5][N:4]([C:7]2[C:8](=[O:33])[NH:9][C:10](=[O:32])[N:11]([CH2:13][CH2:14][CH2:15][N:16]3[CH2:21][C@H:20]4[C@:18]([C:22]5[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=5)([CH2:19]4)[CH2:17]3)[CH:12]=2)[N:3]=1.[ClH:34].CO>C(OCC)C>[ClH:34].[ClH:34].[CH3:1][C:2]1[CH:6]=[CH:5][N:4]([C:7]2[C:8](=[O:33])[NH:9][C:10](=[O:32])[N:11]([CH2:13][CH2:14][CH2:15][N:16]3[CH2:21][C@H:20]4[C@:18]([C:22]5[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=5)([CH2:19]4)[CH2:17]3)[CH:12]=2)[N:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 252532915-(3-methyl-1H-pyrazol-1-yl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 675195745-(3-methyl-1H-pyrazol-1-yl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione dihydrochloride

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

5-(3-methyl-1H-pyrazol-1-yl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione (E28, 51.8 mg, 0.113 mmol) was dissolved and sonicated in Diethyl ether (1 ml) to give a colorless solution. 1.25 M solution of HCl in MeOH (0.225 ml, 0.282 mmol) was added at room temperature. After 3 min and the solvent in vacuo. Obtained 50.8 mg of the title compound as a white powder.

Workup

  1. customto give a colorless solution

Sources & evidence

ORD record
ord-aca2a5847c5f47908212280bee6c9653
Source dataset
uspto-grants-2012_05
Patent number
US08178549B2

Reaction notes

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