反应详情

5-(3-methyl-1,2,4-oxadiazol-5-yl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione (E33, 19 mg, 0.014 mmoles) was dissolved in DCM (1 mL) and 45 μL of HCl (as a 1.0M solution in diethylether) were added. The solution was evaporated under nitrogen stream and the residue was triturated with 0.5 mL of diethylether. Then diethylether was eliminated and the title compound (17 mg, 0.034 mmol) was obtained as a beige solid.

1. customThe solution was evaporated under nitrogen stream
2. customthe residue was triturated with 0.5 mL of diethylether